Endocrine Abstracts

Patients with insulin resistance are often confronted with conception difficulties. Our database of 1178 conceivable female patients with metabolic disorder shows that more than 40% of them suffer from menstrual cycle disorders. More than 25% out of 480 pregnant women with hyperinsulinaemia had at least one assisted reproduction procedure in their lives. 42% of patients with insulin resistance experienced missed abortion, out of them 26% one time, 12% two times. Our aim was to...

Background: Liquorice in moderate doses increases blood pressure (BP) in healthy individuals (NT) as well as patients with hypertension (HT) due to increased cortisol effect. Glycyrrhetinic acid, the active substance in liquorice, inhibits 11beta-hydroxysteroid-dehydrogenase type 2 (11betaHSD2) which converts the active hormone cortisol to the inactive hormone cortisone. Recently it has been reported that treatment with glucocorticoids decreases serum levels of cobalamin (B12)...

Introduction: Primary aldosteronism is an important cause of hypertension. Adrenal venous sampling (AVS) is the gold-standard investigation to determine whether one or both adrenal glands are affected. AVS is a complicated procedure with success rate varying greatly from one hospital to another.Aims: To investigate the success rate of AVS at Landspitali over a 10-year period and compare it to published results from other hospitals....

Introduction: The posture test (PT), developed to distinguish idiopathic adrenal hyperplasia (IAH) from aldosterone producing adenoma (APA), has been postulated as inaccurate. In 2007, standardized diagnostic methods, including PT for subclassification, were introduced in Landspitali University Hospital (LUH), housing the only endocrine department in Iceland. The aim of this study is to review the results of PT performed in LUH in 2007–2016.Methods:...

Introduction: Primary aldosteronism (PA) is an important, potentially curable cause of hypertension (HT) with higher risk of cardiovascular events than essential HT. In 2007, a standardized PA work-up protocol was introduced in Landspitali University Hospital (LUH), housing the only endocrine department in Iceland. The aim of this study is to review characteristics, test results and histopathology for patients diagnosed with PA in 2012-2016 in LUH.Method...

Background: Upto 5% of women will develop diabetes in pregnancy, which is increasing as a result of higher rates of obesity and older age. Diabetes in pregnancy is related increased risk to the mother and to the foetus.Aims: To assess the management of diabetes in pregnancy and monitor outcomes.Methods: This was a retrospective study that included 92 pregnant females, who were diagnosed with gestational diabetes following and oral ...

Introduction: Antiepileptic drugs may cause altered thyroid function in adults according to previous studies. The cllinical impact of this is unclear. The aim of this study was to evaluate thyroid function in patients taking antiepileptic drugs to evaluate a possible clinical impact.Methods: Adult epileptic patients (older than 18 years old) who attended the neurology outpatient clinic at Landspitali University Hospital in Iceland (the only University Ho...

Introduction: Primary aldosteronism (PA) is a potentially curable cause of hypertension. In 2007, a standardized PA work-up protocol was introduced in Landspitali University Hospital (LUH), a tertiary care center for Iceland. The aim of this study is to review treatment response for patients diagnosed with unilateral and bilateral PA in LUH 2007–2016.Methods: All charts for PA-patients aged ≥18, diagnosed 2007–2016 in LUH, were retrospe...

Introduction: There is ongoing debate about how to diagnose and treat unilateral primary hyperaldosteronism (PA). The use of CT scans and adrenal venous sampling (AVS) for the diagnosis of unilateral PA leading to unilateral adrenalectomy is still a matter of discussion. Moreover, some have suggested subtotal adrenalectomy when a detectable nodule is found on imaging studies while others prefer total adrenalectomy. We gathered information on imaging, diagnosis and treatment in...

Endometrial cancer (EC) is estrogen dependent and several enzymes control the local availability of these steroids by activating (i.e. aromatase, sulfatase, 17beta-hydroxysteroid dehydrogenase type 1 – HSD17B1) or deactivating estrogens (sulfotransferase, 17beta-hydroxysteroid dehydrogenase type 2 – HSD17B2). Imbalances in these enzymes are implied in EC development.In the present study, it is evaluated whether imbalances in these enzymes are a...